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by Sandeep Menon (Author), Richard C. Zink (Author)
Get the tools you need to use SAS in clinical trial design
Unique and multifaceted, Modern Approaches to Clinical Trials Using SAS: Classical, Adaptive, and Bayesian Methods, edited by Sandeep M. Menon and Richard C. Zink, thoroughly covers several domains of modern clinical trial design: classical, group sequential, adaptive, and Bayesian methods that are applicable to and widely used in various phases of pharmaceutical development. Written for biostatisticians, pharmacometricians, clinical developers, and statistical programmers involved in the design, analysis, and interpretation of clinical trials, as well as students in graduate and postgraduate programs in statistics or biostatistics, the book touches on a wide variety of topics, including dose-response and dose-escalation designs; sequential methods to stop trials early for overwhelming efficacy, safety, or futility; Bayesian designs that incorporate historical data; adaptive sample size re-estimation; adaptive randomization to allocate subjects to more effective treatments; and population enrichment designs. Methods are illustrated using clinical trials from diverse therapeutic areas, including dermatology, endocrinology, infectious disease, neurology, oncology, and rheumatology. Individual chapters are authored by renowned contributors, experts, and key opinion leaders from the pharmaceutical/medical device industry or academia. Numerous real-world examples and sample SAS code enable users to readily apply novel clinical trial design and analysis methodologies in practice.
Author Biography
Sandeep Menon, PhD, is currently the Vice President and Head of the Statistical Research and Consulting Center (SRCC) at Pfizer Inc., and he also holds adjunct faculty positions at Boston University and Tufts University School of Medicine. His group, located at different Pfizer sites globally, provides scientific and statistical leadership and consultation to various quantitative groups within Pfizer and senior Pfizer management in discovery, clinical development, legal, commercial, and marketing. He is a core member of the Pfizer Global Triad Leadership team. He is very passionate about adaptive designs and personalized medicine. He is the coauthor and coeditor of Clinical and Statistical Considerations in Personalized Medicine (2014). He received his medical degree from Bangalore (Karnataka) University, India, and later completed his master's and PhD in Biostatistics at Boston University.
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