>
✔ 100% Money-Back Guarantee on Eligible Items
✔ Prices Displayed in Your Local Currency
✔ Final Price = No Surprise Import Fees
✔ Complimentary Insured Worldwide Shipping on Qualifying Orders
✔ Select Collector & Specialty Pieces May Require Secured Delivery Handling
by Albee Messing (Author), Alexei Verkhratsky (Editor), Vladimir Parpura (Editor)
This book offers a comprehensive overview of Alexander disease, a rare and devastating neurological disorder that often affects the white matter of the brain and spinal cord.
Its distinctive neuropathology consists of abundant Rosenthal fibers within astrocytes (one of the four major cell types of the central nervous system). Nearly all cases are caused by variants in the gene encoding the intermediate filament protein GFAP, but how these changes in GFAP lead to the widespread manifestations of disease is poorly understood.
Astrocytes, while discovered over a century ago, are themselves still much of a mystery. They exhibit considerable diversity, defy precise definition, and yet actively regulate many aspects of nervous system functioning.
We also have incomplete understanding of Rosenthal fibers, odd structures that contain GFAP as just one of many components. Whether they are toxic or protective is unknown. Moreover, Rosenthal fibers are not absolutely unique to Alexander disease, and are seen sporadically in a wide variety of other conditions, including brain tumors and multiple sclerosis.
GFAP is the third unknown. It is an ancient protein, arising early in the evolution of vertebrates, but its role in normal biology is still a matter of debate. Yet Alexander disease shows, without a doubt, that changing just a single of its 432 amino acids can lead to catastrophe, not just in the astrocytes where GFAP is produced but also in the other cells with which astrocytes interact.
Despite all of the unknowns, much has been learned in the past 20 years, and it is time to share this knowledge. This book is intended for recently diagnosed patients and families, as well as non-specialist researchers interested in this neurological disease. It covers historical origins, the state of current knowledge, and prospects for what lies ahead, with citations to the primary literature given throughout.
- In stock, ready to ship
- ✔ Authenticity Guaranteed — Verified Designer Goods
- ✔ Sourced from Authorized European/U.S. Luxury Distributors
- ✔ Secure Checkout — SSL Encrypted Payments
- ✔ Fast Global Delivery — 3–11 Business Days
- ✔ Easy Returns on Eligible Items
- ✔ 100% Money-Back Guarantee — Full Refund if Not Satisfied
AUTHENTICITY GUARANTEED
Reserved for you — complete your purchase to secure this piece.
OFFICIALLY AUTHORIZED RESELLER
Discover Officially Authorized Authentic Items at STORE7994.com - Certificates Available on Request!
Independently verified for store quality and customer safety.
Trust score: 91/100
All designer items offered by STORE 7994 are sourced from trusted luxury distributors and verified through independent authentication services.
Learn how STORE 7994 authenticates luxury items
Guaranteed Authentic — Includes Brand Documentation & Third-Party Verification Options.
Shipping information
- Free Shipping* on all orders over $300 USD to most countries* Estimated delivery: 2-5 business days Mon-Sat to U.S., CA, EU etc.
- Tracking available: DHL Express
- Store 7994 Shipping policy
- Global delivery in 3–9 business days (location dependent).
- Free Worldwide Shipping $300+. International duties & VAT are calculated by destination country and may be collected upon delivery. UK orders are subject to 20% import VAT upon delivery.
Our innovation isn’t just in the brands we carry — it’s in the way we connect them. From our automation engine that keeps collections globally updated to our commitment to authenticity-first presentation, STORE 7994 exists where timeless design meets modern precision.
Every product we offer is:
Elevated · Intentional · Exclusive · Authentic
STORE 7994 is an authorized reseller of luxury fashion houses. Certificates and proof of authenticity are available to brand owners and partners upon request.
Returns & Refunds
We want you to shop with confidence at STORE 7994. If your purchase does not meet expectations, eligible items may be returned under the conditions below.
Return Eligibility
Items must be unused, unworn, and in original condition with all tags, packaging, and accessories included. Items showing any signs of wear or damage will not be accepted.
Return Window
Return requests must be made within 14 days of delivery.
Return Shipping
Customers are responsible for return shipping costs unless the item is defective, damaged, or incorrect.
Luxury Items
Items valued over $1,000 may be subject to a 7% restocking fee upon approved return.
Non-Returnable Items
For hygiene and product integrity reasons, the following items are final sale once opened or used:
• Underwear
• Fragrances
• Any worn or used items
Made-to-Order Items
Custom-designed products, including STORE 7994 hoodies, are made exclusively for each customer and are final sale. These items are not eligible for return or exchange unless defective or incorrect.
If you receive a defective or incorrect item, please contact us and we will make it right.
International Shipping & Duties
Many of our products ship directly from trusted international partners. Any applicable customs duties or import taxes are calculated at checkout and are non-refundable, even if the item is returned.
Returns & Associated Fees
All approved returns are subject to a $24 return processing fee. For international orders, duties, taxes, and return fees will be deducted from the original payment.
Shipping Policy
Complimentary shipping is offered on orders over $300. Orders below this threshold are subject to standard shipping rates at checkout.
